Hesameddin Razilou
1 
, Seyyed Sina Hejazian
1, Shahed Meshkini
1* 1 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Degenerative nerve diseases are caused by the progressive loss of the structure and function of neurons. Numerous signaling pathways have been suggested to be involved in neurodegenerative disease. Valproic acid is a branched-chain fatty acid used to treat bipolar disorder and epilepsy. Valproic acid modulates immunity by the activation of monocyte-derived macrophages. The present review study focused on the role of Valproic acid in neurodegenerative diseases such as MS and stroke.