Abstract
Background: Systemic lupus erythematosus, is the most prevalent form of lupus. SLE is an immune system sickness wherein the resistant framework goes after its own tissues, causing boundless aggravation and tissue harm in the impacted organs. The purpose of this study was to examine the levels of mRNA for pro- and anti-inflammatory cytokines and B cell amounts in patients with lupus erythematosus.
Methods: This case-control study was performed on 6 patients of those with lupus who were higher than 18 years old and referred to Sina Hospital Clinic to be visited and examined during 2021-2022, and their lupus illness was definitely diagnosed by rheumatology and a dermatologist. The control and patient groups were analyzed using a paired t test.
Results: The results of the present study demonstrated that the number of B cells in the blood samples of the patients was lower than that of the control group. Based on the results, the levels of interleukin (IL)-17, IL-6, and IL-1 in the patient group were higher than in the control group (P<0.005), indicating an increase in inflammation in these patients. Finally, the amount of inhibitory cytokine IL-10 was decreased in these patients.
Conclusion: Overall, pro-inflammatory cytokines were more secreted in patients with lupus and inhibitory cytokines were less; thus, cytokine can be used as a biomarker of inflammation in these patients.