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Biomedical Research Bulletin

Biomed Res Bull. 2024;2(4): 162-171.
doi: 10.34172/biomedrb.2024.22
  Abstract View: 10
  PDF Download: 9

Original Article

Investigating the Therapeutic Effects of Melissa Officinalis on Clinical and Electro Diagnostic Findings of Patients with Type 2 Diabetes

Neda Dolatkhah 1 ORCID logo, Morteza Rajabi 1, Mohammad Rahbar 1, Kazem Shakouri 1, Yasaman Mirzazadeh 2, Sina Janbaz Alamdary 2,3, Fariba Eslamian 1, Tannaz Novinbahador 4,5, Kimia Motlagh Asghari 1* ORCID logo

1 Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
2 Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
3 The Faculty of Medical Sciences of the Islamic Azad University, Tabriz Branch, Tabriz, Iran
4 Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
5 Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Kimia Motlagh Asghari, Email: kimiamtlg@gmail.com

Abstract

Background: Neurological complications and glycemic control are critical to managing type 2 diabetes (T2D). This study aimed to evaluate the effects of a specific intervention with lemon balm capsules on fasting blood glucose (FBS), hemoglobin A1c (HbA1c), and nerve conduction parameters in patients with T2D.

Methods: In this randomized controlled trial, 64 patients with T2D were enrolled and randomly assigned to either an experimental group (n=32) or a control group (n=32). After exclusion, 30 participants in each group completed the study. Baseline characteristics, FBS, HbA1c, and various nerve conduction parameters were measured pre- and post-intervention.

Results: The experimental group demonstrated a significant reduction in FBS levels post-intervention compared to the control group (P=0.02). No significant difference was observed in HbA1c levels (P=0.08). Neurologically, the experimental group had a significant increase in tibial motor nerve action potential amplitude (P=0.001) and higher tibial motor nerve conduction velocity (P=0.03) post-intervention. Significant intra-group changes were also noted in peroneal motor nerve action potential amplitude (P=0.002) and sural sensory nerve potential amplitude (P=0.009). Finally, no significant differences were found in ulnar and median nerve parameters or F-wave latency.

Conclusion: The intervention with lemon balm led to significant improvements in FBS levels and certain nerve conduction parameters in patients with T2D, indicating potential benefits for metabolic control and nerve function.


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Submitted: 14 Nov 2024
Revision: 02 Dec 2024
Accepted: 18 Dec 2024
ePublished: 29 Dec 2024
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