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Biomedical Research Bulletin

Biomed Res Bull. 2025;3(1): 22-27.
doi: 10.34172/biomedrb.8047
  Abstract View: 565
  PDF Download: 71

Review Article

Neuroregeneration: From Molecular Mechanisms to Clinical Applications and Natural Stimulating Agents

Hadiseh Abdollahi 1, Ali Monadi Tabari 2, Kiarash Fekri 2,3* ORCID logo

1 Department of Nursing, Amol School of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran
2 Preclinical Department, Amol Campus of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Paramedicine, Amol School of Paramedicine, Mazandaran University of Medical Sciences, Sari, Iran
*Corresponding Author: Kiarash Fekri, Email: k.fekri@mazums.ac.ir, Email: kiarash.fekri@gmail.com

Abstract

Neuroregeneration (NR) is a process through which the neurons are repaired and recovered. The process can be triggered and modulated physiologically or pharmacologically. Based on the evidence, neuroregenerative pathways are activated in many neurological conditions, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Therefore, targeting these pathways has become an interesting subject for researchers active in this field. In addition, in recent decades, natural remedies have become of interest to researchers, on the one hand, and consumers, on the other hand. Hence, this review aimed to collect the existing evidence about NR, the underlying molecular mechanisms, clinical applications, and the natural stimulating agents. Accordingly, scrutinizing the available literature revealed that many natural agents have the required ability to potentiate NR, each of which can be an interesting topic for further studies.
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Submitted: 14 Dec 2024
Revision: 17 Dec 2024
Accepted: 18 Dec 2024
ePublished: 29 Mar 2025
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