Maryam Hasan Zadeh Navroodi
1 
, Morteza Marashi
1, Faezeh Talaei
1, Mohaddeseh Argha
1, Soheila Mokari
2, Javad Shokri
2, Shalen Kumar
3,4, Tooba Gholikhani
5,6* 1 Faculty of Pharmacy, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran
2 Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3 Research Committee, School of IQ Science, Victoria University of Wellington, Wellington, New Zealand
4 Ra Biotech ltd, Wellington, Wellington, New Zealand
5 Department of Pharmaceutics, Faculty of Pharmacy, Islamic Azad University, Ayatollah Amoli branch, Amol, Iran
6 Nano Ra Pharmaceuticals, Tabriz, Iran
Abstract
Lipid nanoparticles (LNPs) have captured significant attention in the past few years and are widely used. Nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) are two lipid-based NPs with potential applications in research, drug delivery, cosmetics, and other fields. By modifying the size range, they can be used through different routes. Physically stable and targeted SLNs with good release profiles have been designed to overcome the limitations of emulsions and liposomes. NLCs are modified SLNs that enhance loading capacity and stability. Regardless of the preparation method, an initial emulsion is essential. The quality of the initial emulsion can affect the desired size range. This study highlights the critical features required to prepare the initial emulsion wisely and rationally.