Abstract
Background: Kaempferol is a pharmacological kaempferol that can inhibit many inflammatory factors implicated in cancer.
Methods: The present study focused on kaempferol function on the immunity signaling pathway. In this study, Kupffer cells were also isolated with new methods.
Results: Our results indicated that the levels of interleukin 17 (IL-17), IL-33, and IL-6 in supernatants from cultured Kupffer cells from patients were increased after stimulation with high mobility group box-1 (HMGB1), but the levels of these cytokines decreased after using kaempferol to prevent inflammation.
Conclusion: The findings of this study imply that the reduction of the Toll-like receptor 2 (TLR2) pathway and T helper 17 cell polarization may be due to HMGB1 blocking with Kaempferol in hepatocellular carcinoma.