Arin Ghazizadeh
1 
, Raha Amazadeh
2, Mahyar Ziyamolki
1, Amirhossein Olfati
1, Shalen Kumar
3, Tooba Gholikhani
1,2,4* 1 Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
2 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
3 School of Biological Sciences, Victoria University of Wellington, Kelburn parade, Wellington 6021, New Zealand 5 IQ Science Ltd, Wellington, New Zealand
4 Nanora Pharmaceuticals, Tabriz, Iran
Abstract
Aptamers are short single-stranded nucleic acid (DNA or RNA) or peptide sequences with a unique three-dimensional structure that bind to their targets with high specificity and affinity. Aptamers’ small size, fast and cheap production process, low immunogenicity, and high stability have made them attractive molecules in some fields of research, especially in the design of new diagnostic and therapeutic pathways. This review article discusses aptamers’ applications and immunogenic properties in the pharmaceutical sciences.