Maad Rayan Publishing Company Biomedical Research Bulletin 2980-9924 3 2 2025 06 30 The Efficacy of Cold-Water Immersion in Mitigating Fatigue in Soccer 66 71 10.34172/biomedrb.9059 EN Mostafa Khani https://orcid.org/0000-0003-3376-9513 Mohammad Shoghi https://orcid.org/0009-0001-2015-7510 Kimiya Sadri https://orcid.org/0000-0001-5102-9469 REVIEW 10.34172/biomedrb.9059 2025 03 20 2025 05 21 Soccer, as the world’s most popular sport, features numerous organized and prestigious competitions and leagues across the globe. Throughout a typical nine‐month season, soccer players engage in frequent training sessions and a high number of matches, exposing them to both substantial physical volume and intensity. Such demanding schedules often lead to fatigue, as evidenced by elevated markers of muscle damage, inflammation, lactate accumulation, delayed onset muscle soreness (DOMS), and increased ratings of perceived exertion (RPE). If both central and peripheral fatigue are not promptly addressed, subsequent performance may decline, and in some cases, serious injuries may occur. Among the various recovery modalities employed, cold therapy, particularly cold-water immersion, has gained significant popularity. This study systematically examined the effectiveness of cold-water immersion in alleviating fatigue-related factors among soccer players. English-language studies retrieved from the PubMed and Google Scholar databases were analyzed. Findings revealed that cold-water immersion can enhance subsequent performance in soccer players by reducing levels of creatine kinase (CK), lactate dehydrogenase (LDH), lactate, DOMS, and RPE, thereby moderating post-activity fatigue. Although a minority of studies report negligible or null effects of cold-water immersion on recovery in soccer players, the overall evidence supports its use as a cost-effective, accessible, and beneficial method for improving subsequent performance.