Maad Rayan Publishing Company Biomedical Research Bulletin 2980-9924 3 1 2025 03 29 The Impact of Resistance Training, Whey Protein, and Creatine Supplementation on Diabetes-Induced Sarcopenia 17 21 10.34172/biomedrb.9058 EN Mostafa Khani https://orcid.org/0000-0003-3376-9513 Mohammad Shoghi https://orcid.org/0009-0001-2015-7510 Kimiya Sadri https://orcid.org/0000-0001-5102-9469 Journal Article 10.34172/biomedrb.9058 2025 02 20 2025 03 04 Diabetes mellitus is a global disorder affecting blood glucose regulation, with a steadily increasing prevalence. Predominantly, type 2 diabetes accounts for the majority of cases, and if left undiagnosed or inadequately managed, it may lead to several complications, including sarcopenia, kidney failure, visual impairment, and cardiovascular diseases. In patients with diabetes-induced sarcopenia, the simultaneous reduction in muscle mass and strength further complicates glycemic management. This systematic review explored the impact of resistance training and the supplementation of whey protein and creatine on muscle strength, muscle mass, and glycemic indices in these individuals. A thorough search of English-language articles in Google Scholar and PubMed was conducted using relevant keywords. The evidence indicated that resistance training enhances muscle strength and mass while improving glycemic control, as observed in reductions in hemoglobin A1c levels. Similarly, whey protein and creatine supplementation were associated with beneficial effects on postprandial glycemia and the preservation of muscle integrity. Overall, these interventions, when applied following appropriate guidelines, offer promising strategies for the prevention and management of both diabetes and sarcopenia.