Maad Rayan Publishing Company Biomedical Research Bulletin 2980-9924 2 3 2024 09 30 How Oxidative Stress Modifies the Immune Response Landscape in Cancer 140 161 10.34172/biomedrb.2024.21 EN Somayeh Ashrafi https://orcid.org/0000-0001-5605-0443 Neda Zahmatkesh Melika Khanzadeh Tehrani Nastaran Hadizadeh Sara Rahimzadeh Mehdi Mahdavi Mohammad Abdollahi https://orcid.org/0000-0002-0193-3692 Mohammad Hossein Yazdi https://orcid.org/0000-0001-8567-8555 REVIEW 10.34172/biomedrb.2024.21 2024 08 20 2024 09 17 There is an increasing body of evidence which proves that excessive production of toxic reactive species, primarily reactive oxygen species (ROS), damages many biomolecules, cell structures, and functions. They participate in various human pathological processes, particularly aging, neurodegenerative disorders, uncontrolled inflammation, and cancer. Inflammation is a biological response of the host’s immune system, accompanied by the involvement of various immune cells, blood vessels, and molecular mediators. Therefore, in this review, we discussed the relationship between inflammation and oxidative stress and their relationship with cancer. We also discussed the role of the immune system in inflammation, oxidative stress, and cancer. Undoubtedly, further studies about ROS and inflammatory interactions in the stimulation of immune responses can open up new horizons for researchers to design an innovative immunotherapeutic strategy for chronic inflammatory diseases and cancer-related inflammation (CRI).