Maad Rayan Publishing Company Biomedical Research Bulletin 2980-9924 2 2 2024 06 28 Investigating the Expression of Long Non-coding RNA Gene BANCR in Tumor Tissues and Adjacent Non-tumor Tissues of Patients with Breast Cancer 70 74 10.34172/biomedrb.2024.11 EN Raha Nikanfar https://orcid.org/0009-0009-1365-8067 Alireza Nikanfar Mahsa Nikanfar https://orcid.org/0009-0004-6328-452X Journal Article 10.34172/biomedrb.2024.11 2024 06 08 2024 06 17 Background: Breast cancer is one of the most common types of cancer worldwide, and long non-coding RNAs (lncRNAs) have been implicated in its development and progression. Methods: In this study, we investigated the expression of BRAF-activated non-coding RNA (BANCR) in tumor tissues and adjacent non-tumor tissues of 123 breast cancer patients. Results: Our results showed that the expression of BANCR was significantly higher in tumor tissues compared to adjacent non-tumor tissues. Based on the results, the mean fold change was 7.894 (P<0.001). Moreover, the result revealed that the expression of BANCR was increased in patients with lymph node invasion in comparison to patients without lymph node invasion (LogFC=1.358, P<0.001). Conclusion: The study findings suggest that BANCR may be a potential biomarker for breast cancer; however, further research is needed to confirm these results.