Maad Rayan Publishing Company Biomedical Research Bulletin 2980-9924 1 2 2023 06 29 Classic Kaposi Sarcoma: An Unusual Presentation in an HIV-Negative Man 84 86 10.34172/biomedrb.2023.15 EN Mahsa Eslami https://orcid.org/0009-0008-5545-1518 Sanaz Alizadeh Faezeh Alavi Sina Safari https://orcid.org/0000-0002-0424-4016 Journal Article 10.34172/biomedrb.2023.15 2022 11 25 2023 01 01 Kaposi sarcoma (KS) is a type of cancer that develops in blood vessels of the mouth, lymph nodes, and lungs. Our case report is about a 66-year-old man with purple patches and plaques, as well as nodules distributed in the legs and arms. Biopsy of the skin lesions showed angiomatous proliferation of small vessels with mild perivascular lymphocytic infiltration with plasma cells. We started chemotherapy for this disseminated form of Kaposi sarcoma.