Maad Rayan Publishing Company Biomedical Research Bulletin 2980-9924 1 2 2023 06 29 Application and Immunogenicity of Aptamers in Cancer Therapy 66 76 10.34172/biomedrb.2023.13 EN Arin Ghazizadeh https://orcid.org/0000-0002-0100-7461 Raha Amazadeh Mahyar Ziyamolki Amirhossein Olfati Shalen Kumar Tooba Gholikhani https://orcid.org/0000-0002-9714-7257 REVIEW 10.34172/biomedrb.2023.13 2023 04 24 2023 06 03 Aptamers are short single-stranded nucleic acid (DNA or RNA) or peptide sequences with a unique three-dimensional structure that bind to their targets with high specificity and affinity. Aptamers’ small size, fast and cheap production process, low immunogenicity, and high stability have made them attractive molecules in some fields of research, especially in the design of new diagnostic and therapeutic pathways. This review article discusses aptamers’ applications and immunogenic properties in the pharmaceutical sciences.