Maad Rayan Publishing Company Biomedical Research Bulletin 2980-9924 1 2 2023 06 29 Coma Following the Sinopharm COVID-19 Vaccine: A Case Report 87 89 10.34172/biomedrb.2023.16 EN Nazila Deznabi https://orcid.org/0000-0001-6168-626X Nasrin Abolhasanpour https://orcid.org/0000-0002-2606-5772 Hanieh Salehi-Pourmehr Journal Article 10.34172/biomedrb.2023.16 2023 04 17 2023 06 21 The Chinese Sinopharm vaccine was produced in 2020 as an effective preventive measure against COVID-19. The low and non-serious adverse effects of the Sinopharm COVID-19 vaccine were reported in the literature. This report presents a 70-year-old man who underwent surgical burr-hole evacuation of the hematoma in the right and left parietal and frontal areas. Six days after discharge from the hospital, he received Sinopharm vaccine, and three days post-vaccination, he was referred to the hospital with signs of weakness and lethargy. During the hospitalization, the patient had extensive tonic-clonic seizures and then went into a coma. A close follow-up was done for clinical, laboratory, and imaging studies during his stay in the hospital. After 10 days of appropriate medication, the seizure stopped.