Maad Rayan Publishing Company Biomedical Research Bulletin 2980-9924 2 1 2024 03 29 A Review of Osmotic Pump Applications as a Reliable Drug Delivery System in Pharmaceutical Sciences 29 36 10.34172/biomedrb.2024.05 EN Samar Mahari https://orcid.org/0000-0003-1233-7324 Seydeh Halimeh Najafi https://orcid.org/0000-0001-5240-9199 Salar Masoomzadeh https://orcid.org/0000-0002-6748-4391 Shalen Kumar https://orcid.org/0000-0001-8808-0604 Tooba Gholikhani https://orcid.org/0000-0002-9714-7257 REVIEW 10.34172/biomedrb.2024.05 2024 01 20 2024 03 16 Systems known in the pharmaceutical sciences have less use for drug release and control. In addition, these standard systems in pharmacy have no effective control over drug concentrations. The main problem with conventional drug delivery systems (DDS) is the unpredictability of different plasma concentrations. However, drug control systems have provided an excellent way to release the drug. In this regard, osmotic pumps are the best and most promising systems for the controlled delivery and release of drugs. They are commonly used for oral and injectable use, several of which are also commercialized and widely accepted by patients, especially the antihypertensive products. The purpose of this study is to introduce and compare different types of osmotic pumps in pharmacy.